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OGT-mediated O-GlcNAcylation increases CDK5 activity, which phosphorylates ACSS2 at S267, inhibiting its degradation and promoting the synthesis of acetyl-CoA from acetate [74]

112,113 A single dose of CTX310 in non-human primates resulted in 70% mean editing of ANGPTL3 in the liver, an over 85% reduction in plasma ANGPTL3 protein, and a 60% reduction in TG, with effects lasting beyond a year and only transient liver enzyme elevation

Dimensions: 7771 x 4498 px | 65.8 x 38.1 cm | 25.9 x 15 inches | 300dpi Date taken: 29 June 2020 Photographer: MOLEKUUL/SCIENCE PHOTO LIBRARY

3.3 Glaucoma Glaucoma, the second leading cause of irreversible blindness worldwide, is characterized by compromised axonal function in the optic nerve head