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The NIK/NF-B signaling axis induced by SMAC mimetics also mediates induction of MHC class I expression, increasing cancer cell sensitivity to T cell-mediated killing and improving immune checkpoint blockade therapy [168]

& Hoffmann, A

Short-term secretagogue use producing physiological GH elevation differs substantially from the chronically supraphysiological levels seen in acromegaly, but awareness of these risks remains important