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In 2013, a clinical trial comparing phentermine as monotherapy or as part of a combined therapy, took place and resulted in a weight loss of 5.1% at 28 weeks follow-up period in favor of the combined phentermine/topiramate group.(see Table 10) Table 10

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Persistent fatigue, brain fog, low mood, weight gain, tingling in the hands or feet, frequent illness, post-COVID fatigue, or feeling generally "off" despite eating well and sleeping enough, especially if you're vegetarian, vegan, over 50, on metformin or a long-term acid reflux medication, or have a history of low B12 or pernicious anemia

Many types of psychotherapy can be helpful, and finding a good fit may depend on an individuals preferences