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225,226,227,228 Backbone modification The modification strategies used in first-generation NADs have focused on modification of the phosphate backbone, mainly using other types of groups to replace the non-bridging oxygen atoms in the phosphate backbone, such as phosphorothioate (PS), methyl phosphate, and boranophosphate

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The paper that named CJC-1295 Jett and colleagues in Endocrinology , 2005 identifies CJC-1295 explicitly as the tetrasubstituted form of hGRF(1-29) carrying an added N-3-maleimidopropionamide derivative of lysine at the C-terminus [1]