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The SphK/S1P axis has been reported to regulate the host immune system and to exert pro- or anti-viral effects in different types of viral infections by interfering with intracellular signaling pathways (56,57)

In contrast, studies in SMA type 2 patients exhibit reduced cortical thickness in the precentral gyrusincluding the primary motor CRTX (M1)that correlates with motor decline, indicating neurodegeneration [16]