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According to studies conducted by Jiang Ji and others, ionizing radiation affects primary keloid fibroblasts (KFb), causing damage to their DNA [90]

Molecular pharmacokinetics of catharanthus (vinca) alkaloids

Studies demonstrate that SLC7A11 activates mechanistic target of rapamycin complex 1 signaling, which phosphorylates 4E-binding protein 1 to enhance GPX4 protein translation

Therefore, mutations affecting any of its subunits can result in disruption to mitochondrial respiration and result in reliance on the glycolytic pathway for the production of ATP