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Bibcode:2008Natur.452..707T

Conclusions High-throughput screening of 5830 compounds was used to identify inhibitors of GST P1-1, an enzyme overexpressed in certain cancers that is responsible for drug resistance

The free parameters are determined from the experimental data

This is a conundrum that, I believe, can only be resolved by randomly assigning a large group of participants to either taking the supplement or taking a placebo, following them for years, and comparing them