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If the ratio of OXPHOS/ET capacity (OXPHOS-control ratio or P/E ratio) is less than one, decoupled respiration overestimates the apparent reserve capacity for oxidative phosphorylation with respect to ROUTINE-respiration of living cells

Penicillamine was selected as the nucleophile of choice owing to its capacity to covalently bind 4-HNE and thus limit its bio-availability 76

Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription

However, statinfibrate combination regimens have potential adverse effects on skeletal muscle, including myopathy