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This effect is attributed to the upregulation of hepatic -catenin, which helps to restore the integrity of tight junctions and normalize the expression of bile transport proteins (OATP2, BSEP, and NTCP1), ultimately inhibiting intrahepatic bile duct dilation, cholestasis, and the progression of fibrosis

Age dependency of estrogen responsiveness in the uterus and adipose tissue of aromatase-knockout (ArKO) mice

Elevated circulating eHSP72 levels correlate with chronic inflammation, insulin resistance, and pancreatic -cell dysfunction in T2DM patients

Furthermore, it regulates gene expression, fostering the growth and differentiation of diverse cell types throughout the body