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Clinicians must supervise use of both peptides because side effect risk depends on metabolic health, endocrine function, and existing medical conditions

Evidence consistent with intravascular phagocyte activation in meta-inflammation and T2DM includes leukocyte adhesion to the endothelium and formation of neutrophil extracellular traps (NETs), which can promote thrombophilia and directly injure endothelial cells [984,985,986,987,988]