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Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]

Overexpression of a zinc finger transcription factor (ZFTF), which is significantly induced by MT and serves as one of the most upregulated DEGs, can further increase biomass and astaxanthin synthesis in P