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Description

A low ratio suggests ongoing oxidative damage

In the 1940s and 1950s, high-dose folic acid was used to reverse the megaloblastic anemia of B12 deficiency, but that treatment masked the underlying deficiency and possibly worsened its neurological progression

In another embodiment, a method is provided for a one-step synthesis comprising reacting a reducing agent (e.g., lipoic acid) with a halogenated choline (e.g., bromocholine bromide) to yield a choline ester