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Biol Psychiatry 2006;59(11): 1006-1020

To establish cysteine deprivation cell models, HepG2, Hepa1-6, and KYSE-150 cells were maintained in a cell culture medium without cysteine for 48 h

Similarly, in bipolar disorder, particularly during depressive episodes, patients exhibit altered energy metabolism marked by increased lactate levels and decreased glucose and glycine levels, which parallels results in ME/CFS that suggest TCA impairment and energy metabolism dysregulation (Yamano et al., 2016