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Epub 2002/09/12

doi: 10.1002/stem.2575 112 DuanLXuLXuXQinZZhouXXiaoYet al

Furthermore, studies have shown that ovarian cancer cells with elevated levels of indoleamine 2,3-dioxygenase 1 (IDO1), an enzyme that catalyzes the conversion of tryptophan to l-kynurenine (Kyn), exhibit platinum resistance by downregulating the ROS/p53 pathway (82)