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Genes upregulated by GSTO1 siRNA showed significant enrichment of amino-acid deprivation response-related gene sets 29

A oligomers are considered the most neurotoxic species in AD since the levels correlate with the presence of synaptic loss and, in turn, cognitive symptoms, particularly during the earliest stages of the disease

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Such a limitation can be overcome, for example, by including a copy of the gene sequence for a xenobiotic ortholog of the native protein in with the gene sequence of the novel variant gene in one or more cycles of DNA shuffling