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Proton pump inhibitors and H2 receptor antagonists, commonly used for gastroesophageal reflux disease and peptic ulcer disease, may affect vitamin B12 status through multiple mechanisms

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Metabolic Significance ERRs are master regulators of cellular energy metabolism, controlling the expression of genes involved in fatty acid oxidation, oxidative phosphorylation, the citric acid cycle, and mitochondrial biogenesis

333 It is reported that LRRK2 G2019S dopaminergic neurons exhibit a decreased NAD + pool and a reduced sirtuin deacetylase activity, correlating with elevated acetylation of sirtuin substrates p53, -tubulin and SOD2