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COXs In skin, as in other tissues of the human body, there are two isoforms of cyclooxygenases: the constitutive isoform, COX-1, which is constitutively expressed in most human tissues, including skin [101, 102] and the inducible isoform, COX-2 [103], which shares 60% amino acid homology with COX-1 [104]

Salmain M, Gaschard M, Baroud M, Lepeltier E, Jaouen G, Passirani C, Vessieres A (2023) Thioredoxin reductase and organometallic complexes: a pivotal system to tackle multidrug resistant tumors

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Patients, who reported neuropathic symptoms and were submitted at least 2 months of neurotoxic ChT, were included