In addition, the oldest orphan nuclear receptor estrogen-related receptor (ERR), an important regulator of metabolic gene transcription and innate immune function, including those induced by toll-like receptor (TLR) and antimicrobial activities against intracellular bacterial infection [147], facilitated post-translational activation of autophagy by deacetylating various autophagy-related proteins, including ATG5, BECN1, and ATG7
PMID 25732744
doi: 10.1016/j.yexcr.2010.08.011 145 OkaniwaNSasakiMMizushimaTOgasawaraNFunakiYJohTet al
3.1.4 Carotenoids (-carotene, lutein, etc.) Carotenoids are a series of potent antioxidants, primarily involving-carotene, lutein, and others, with the ability to grab and neutralize oxygen free radicals like singlet oxygen ( in vivo through quenching singlet oxygen (1O2) and other reactive oxygen species (ROS) by physical and chemical reactions ( To be specific, carotenoids can efficiently neutralize parlous free radicals by physical quenching of singlet oxygen (1O2) and other ROS, which is importaant for protecting the integrity of cell membranes and organelle functions, particularly under conditions of oxidative stress ( Hence, carotenoids, with their potential antioxidant features, is of great importance in keeping the structure and function of periodontal tissues from oxidative damage, emphasizing their possible application in keeping oral health
