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SCFAs inhibit pro-inflammatory cytokine (IL-6, IL-12) release from DCs via GPR109A and HDAC suppression, skewing T cell differentiation toward tolerance (Kleuskens et al., 2022)

In one randomized control-trial comparing an L-carnitine supplementation group of patients with a group taking placebos, the treatment group experienced a significant reduction in body fat compared to placebo (-3.1kg vs -0.5kg) 1

The activities of 2-OGDDs are affected by the intracellular level of -KG, succinate, fumarate, or 2-HG

Another strategy is to use 4-hydroxythalidomide as the starting building block to create ether-linked 4-hydroxythalidomide derivatives 96