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The gastric epithelium is considered to have greater tightness, depending on the number and depth of tight junction strands, than the esophageal epithelium

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In published clinical trials, once weekly cagrilintide has been reported to produce dose dependent body weight reductions in participants with overweight or obesity, and it has also been studied in combination programmes with semaglutide, where trials reported greater weight loss than either component alone

Individuals considering this procedure should discuss all possible risks and complications with their healthcare provider before undergoing treatment