glutathione peroxidases review The role of peroxidase-1 in health and disease Frontiers | Research progress of

During high-intensity exercise, the increased production of free radicals is primarily due to the increased oxygen consumption and the increased energy production by the mitochondria, which produce ATP that provides energy for the transportation of oxygen and other molecules

h Includes asthenia, fatigue, and lethargy

Potential mechanisms include membrane disruption, formation of protein pores, and generation of toxic oxidation products as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE).33 From a therapeutic point of view, pharmacological inhibitors of ferroptosis may be used to prevent ferroptosis-induced tissue injury

Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease