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Furthermore, SGLT2 inhibitors can enhance HIF-2 activity via a mechanism that relies on SIRT1 (276)

1995 Oct;19(4):523-8.PMID: 7590404 Herzenberg LA, De Rosa SC, Dubs JG, Roederer M, Anderson MT, Ela SW, Deresinski SC, Herzenberg LA

These microbial alterations coincided with PTSD symptomatology, BBB dysfunction and hippocampal neuroinflammation, which was confirmed by increased proinflammatory cytokine levels IL-1 and IL-6 (Tanelian et al., 2023)