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Additionally, a meta-analysis of 46 randomized trials, including 171,244 participants, found that supplemental vitamin E, singly or in combination with other antioxidants, did not significantly alter the risk of all-cause mortality (126)

Reactive oxygen species can oxidize cellular GSH, leading to the loss of intracellular redox homeostasis and activation of the apoptotic signaling cascade

Chemical modifications, such as the substitution of -Br, -Cl, -CH3, and -NO2 groups onto natural flavonoids, modulate the gut microbiota by slowing harmful bacteria and promoting beneficial bacteria (Perz et al