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interstitial fibrosis and residual restrictive pulmonary diseases may be developed [28]

Antitumor The TME exhibits distinctive characteristics, including hypoxia, acidic pH, and elevated levels of reduced glutathione (GSH) and H 2 O 2 , which collectively create a conducive environment for tumor proliferation, invasion, migration, adhesion, and neovascularization

The impairment of immune cell function and aberrant expression of suppressor T cell response are widely recognized consequences of the interaction between programmed cell death protein-1 (PD-1) and its ligand, programmed cell death ligand-1 (PD-L1), in pathological conditions such as cancer and chronic infection (107)

Our work defines PRMT7-dependent GLUD1 methylation as a critical post-translational regulator of gastric cancer progression, though the precise mechanisms coordinating methylation and ubiquitination require further exploration