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Notably, the upregulated metabolites were related primarily to glutathione metabolism, including key precursors for glutathione synthesis ( -glutamylcysteine and acetylcysteine), metabolites involved in glutathione catabolism and its byproducts (cysteinylglycine and Cys-Gly), and both oxidized and reduced forms of glutathione (GSSG and GSH) and glutathione disulfide

Thus, the use of combined medications to address the drug resistance arising from Keap1 mutations represents a promising novel approach to combat chemotherapy resistance in clinical settings

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In the second part of this project, NAA was eliminated from 6 groups at different time periods