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Diabetologia 60:15661576 Salpeter SR, Greyber E, Pasternak GA, Salpeter EE (2010) Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus

These examples highlight how the intestinal epithelium is continuously exposed to harmful chemicals present in the diet which can attenuate its efficacy in limiting the systemic entry of luminal components

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