glutathione peroxidase reduced 4: a new player in neurodegeneration? Antioxidant Mechanisms of the Protective

Wu G, Bazer FW, Johnson GA, Knabe DA, Burghardt RC, Spencer TE, Li XL, Wang JJ

Superoxide radical and hydroperoxyl radical An important electron transfer reaction occurs in mitochondria via leakage of an electron from the electron transfer chain to oxygen during oxidative phosphorylation, resulting in the formation of a primary radical, superoxide radical anion (O 2 + e O 2 ) (Boveris and Cadenas 1982)

As illustrated in Figure 7, a correlation analysis revealed associations between 20 differentially abundant metabolites and 7 distinct microbial genera, which formed distinct clusters

Therefore, one of the possible mechanisms that can explain the above phenomenon is that at higher concentrations, glucose spares glutamine entry into the tricarboxylic acid (TCA) cycle, which can result in high glutamine levels inside the cell [30]