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doi:10.1016/j.jacc.2017.10.064 78

Structures were then refined with Buster (Smart et al., 2012) and manually adjusted with Coot ( Crystal data, diffraction, and refinement statistics are shown in Table 1 and all structural figures were generated with Pymol (Schrdinger LLC)

This dose was chosen based on a previous dose-escalation study and subsequent work demonstrating its efficacy to drive weight loss in a short period of time 8

A typical titration might start at 0.5 mg per week, increase to 2 mg, and eventually reach doses of 8 mg or 12 mg depending on your providers recommendation