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Among the regulatory pathways, ferroptosis is the most specific form, Due to the accumulation of intracellular iron ions, lipid peroxidation reaction occurs ( The cystine-GSH-GPX4 axis is a major pathway against ferroptosis in mammals ( Intracellular GSH levels are much higher than extracellular GSH levels, thus, they can participate in REDOX reactive drug delivery and are associated with tumor drug resistance ( 2.2 Phospholipid metabolism pathway Increased lipid peroxidation is a classic feature of.ferroptosis As early as the 1950s, it was reported that selenium, vitamin E and cysteine have certain inhibitory effects on lipid peroxidation