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An emerging mechanism of ferroptosis-like cell death points to cysteine loss as a key trigger, with one study demonstrating that erastin-induced cysteine deprivation triggered an alternative ferroptosis-like death pathway distinct from GPX4 inhibition, and that cysteine levels themselvesnot just glutathione levelswere the primary determinant of cellular fate

The approval was based on a three-arm, parallel Phase I study that compared the pharmacokinetics, safety and immunogenicity of Tofidence to reference tocilizumab in healthy volunteers

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