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however, the strength of causal evidence varies across different resistance models.In BRAF inhibitor resistance, PHGDH knockdown reverses resistance, and exogenous serine supplementation rescues the resistant phenotype

This design facilitates precise therapeutic delivery, improving bioavailability and reducing systemic toxicity

For those specifically targeting skin concerns like hyperpigmentation or uneven tone, studies have used dosages ranging from 500 mg to 1,000 mg daily, often divided into two doses rather than taken all at once