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PMID 21635694

186 These findings shed light on the mechanism of lactylation in immunosuppression, metabolic reprogramming, and chemoradiotherapy resistance in GBM, suggesting that targeting glycolysis-derived lactylation could be a potential combined therapeutic strategy for GBM

CYP 450 Families and subfamilies Foye's principles of medicinal chemistry CYP Biotransformations Chemically diverse small molecules are converted, generally to more polar compounds Reactions include: Aliphatic hydroxylation, aromatic hydroxylation Dealkylation (N-,O-, S-) N-oxidation, S-oxidation Deamination Dehalogenation Oxidative Phase-I involving cytochrome P-450 enzymes: Aliphatic hydroxylation: Mainly occur on the ultimate () or penultimate (-1) carbon atom in the structure

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