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Thus, the extraordinarily high phosphoryl-transfer potential of PEP is due primarily to the subsequent enolketo tautomerization of pyruvate, which provides a strong thermodynamic driving force

However, most pediatric trials to date have been small, open-label, and lacked long-term follow-up

[of outstanding importance] o This review provides a comprehensive roadmap for future research on brain fog, emphasizing the development of harmonised cognitive protocols, validated measurement tools, and biomarker-based stratification