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Summary Keywords autologous organ-on-chip, precision medicine, disease modelling, tissue engineering, drug testing Citation Bisconti F, Abreu H, Nguyen TD, Stolfi F, Corbezzolo N, Gigli G, Raineri D, Cappellano G, Polini A, Gervaso F, Chiocchetti A and the FLAMIN-GO Consortium (2025) My cells, my model: immune-competent autologous organ-on-chip systems as a new paradigm in precision medicine

PMID: 25038008

In populations with schizophrenia, dysfunction in glutamate metabolism and decreased glutamate levels in the pre-frontal cortex have been reported.68 The addition of cysteine has been shown to modulate glutamate levels through glutamatecystine exchange, and GSH has been shown to modulate the binding of glutamate to N -methyl-d-aspartate receptors.69 N -acetylcysteine may be beneficial in the treatment of schizophrenia by targeting both oxidative stress and glutamatergic dysfunction, suggesting that the phenotype is a result of interactions of multiple neurotransmitter pathways70 that interact with oxidative and inflammatory systems, which are additionally implicated in the disorder