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A randomized, double-blind, placebo-controlled crossover clinical trial found that treatment with oral ALA (1200 mg/8 weeks) resulted in a significant reduction in both waist circumference and body weight [44]

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Animal and ovary grouping, sample picking, sample size estimation, and animal and ovary inclusion/exclusion For grouping, sample picking, and sample size estimation of the mouse experiments, under the prerequisite of the 3R principle, we employed enough mice to ensure that the results were credible