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FIGURE 4 3.1 Modulation of inflammatory signaling pathways 3.1.1 Inhibition of nuclear Factor- B (NF- B) pathway Glycyrrhizin exerts anti-inflammatory effects and directly protects hepatocytes by regulating genes such as interleukin-4 (IL-4), fibroblast growth factor 10 (FGF10), inhibiting Inhibitor of kappa B (I B) phosphorylation and p65 nuclear translocation to suppress NF- B activation in hepatocytes, thereby reducing the production of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) (Hsiang et al., 2015

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Small Intestinal Bacterial Overgrowth (SIBO) "consumes part of the ingested macro- and micronutrients and may therefore cause malnutrition." 2) Malabsorption: Additionally, intestinal hyperpermeability (leaky gut) is common amongst those with chronic fatigue