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IL-1 enhances permeability via activation of the Transforming Growth Factor-(TGF-)/RhoA/v6 integrin pathway (27)

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Methods Trial oversight The trial was designed and conducted at the University of Texas MD Anderson Cancer Center (MDACC), registered under clinicaltrials.gov identifier NCT03274258, approved by the MDACC institutional review board (IRB)/independent ethics committee (IRB protocol 2017-0201) and conducted in accordance with Good Clinical Practice guidelines, defined by the International Conference on Harmonization