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3, 10, 11, 13, 15, 16, 20, 45, 47, 48 Two of these studies did not include a healthy comparison group 13, 45 and one did not report group means or effect sizes for Glx, 48 but for the remaining seven studies, we calculated the effect size (Cohens D) from the difference between group means (ADHDcontrol) and the pooled standard deviations for Glx/Cr or Glx

Among the biomarkers discussed, some are approaching clinical utility and have shown promise for bedside application

Document weekly dose, date, and injection sites to maintain consistency

Even in cases where tumors initially respond to targeted therapy, tumor cells can activate compensatory signaling pathways that bypass the inhibitory effects of the drug, ultimately driving tumor relapse and progression [3, 4]