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The increase of DA promotes the dopaminergic transmission by regulating (inhibiting) other proteins: VMAT2, whose inhibition induces the DA liberation from vesicular storage and the concomitant release of cytosolic DA via DAT reverse transport [33, 187], SERT (with weaker affinity), and MAOA and MAOB [153]

but not necessarily where the infection is located or whether current symptoms are caused by herpes

Up to now, powerful genetic tools allowed clarification of the significance, dispensability and potential of cystine transporters for ferroptotic cell death in PDAC and breast cancer ( via xCT ( A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport ( in vitro studies as efficient inducer of ferroptosis in many different cancer types, including breast, PDAC, lymphoma, renal, brain and ovarian cancers (50, 51) and sorafenib (52)

This chapter has the aim of disclosing the role of selenide or hydrogen selenide (Se 2 or HSe ) as central metabolite of selenium and as an important antidote of the electrophilic mercury forms (particularly, Hg 2+ and MeHg)