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DOX was analyzed using a C18 column (150 4.6 mm, 5 m) with a mobile phase of acetonitrile/0.1% phosphoric acid (30:70, v/v) at a flow rate of 1.0 mL/min, 25 C, and a detection wavelength of 480 nm (injection volume: 20 L)

Analysis of permeation flux and permeation coefficients indicated superior corneal permeability per unit time and area, suggesting potential application for the prevention and treatment of preoperative and postoperative inflammatory responses in cataract surgery [233]

The absence of liver toxicity with orforglipron, despite its primary route of elimination through hepatic CYP3A-mediated metabolism, suggests that the hepatotoxicity observed with danuglipron and lotiglipron was related to the specific chemical structures of those molecules rather than to the class of small-molecule GLP-1 agonists as a whole

The experiments were approved by the Commission on Biomedical Ethics of the Zakusov Institute of Pharmacology