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doi: 10.1016/j.nbd.2021.105596

Longitudinal clinical studies demonstrate progressive decline in PGC-1 activity correlating with heightened inflammatory markers and oxidative damage in AT specimens (120, 126)

Moreover, pathologic examination of H&E stained tumours, revealed severe bleedings and necrosis in the lungs infiltrated by NKX21 tumours, but not in vector control tumours, highlighting a more aggressive phenotype of NKX21 tumours