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Reichermeier et al , 2020

FOXO4-DRI Potential Selectivity As mentioned, FOXO4-DRI is believed to selectively disrupt the binding of FOXO4 to p53, which may lead to the activation of p53, which in turn may stimulate the process of removing senescent cells

Nephrotoxicity may occur due to expression of the drug target in kidney cells and is influenced by the role of the kidney in the metabolism and clearance of different drug classes (macromolecules versus small molecules) even when targeting the same receptor (Supplementary Table 2)

BPC157 promotes cell proliferation and tube formation in endothelial cells Angiogenesis refers to the formation of new blood vessels from preexisting capillaries or postcapillary venules, a process critically dependent on the activation, proliferation, and migration of endothelial cells [14]