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4.2.2 Ferroptosis exacerbates secondary brain injury post-ICH Secondary brain injury after ICH results from complex interplay between brain edema, neuroinflammation, oxidative stress, and programmed cell death including autophagy, apoptosis, and ferroptosis (193)

see Table S.2 in SI) on the basis of confusion matrices (Fig

DOI: 10.1016/j.parkreldis.2012.11.009

The amino acid sequence is in the public domain and there is no composition-of-matter patent worth pursuing, so no commercial sponsor will fund the hundreds of millions a Phase IIIII development programme costs for a compound it cannot exclusively monetise