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Future research should integrate nanodelivery technologies like HDL-based nanodrug systems to enhance tissue-specific targeting for precise renal cholesterol metabolism control ( 4.3 Emerging therapeutic technologies Nanomedicine demonstrates unique advantages for DN treatment, centered on precise renal targeting and synergistic modulation of multiple pathological pathways (Figure 4)

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[35] Protective airway reflexes are preserved, [36] and it is sometimes possible to administer ketamine anesthesia without protective measures to the airways