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Collectively, these findings suggest that BL exerts cytoprotective effects against oxidative stressinduced apoptosis through two complementary mechanisms: preservation of intracellular redox homeostasis and coordinated regulation of the pro-inflammatory NF-B/iNOS pathway alongside the cytoprotective Nrf2/HO-1 signaling axis (Huang et al., 2022

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Association between epilepsy and depression Epilepsy and depression share complex comorbidity mechanisms, involving factors such as seizure focus localization, sex differences, genetic susceptibility, and specific structural and functional brain alterations, including disruptions in emotion-regulation neural circuits (e.g., involving the hippocampus, amygdala, and prefrontal cortex), changes in gray and white matter integrity, and altered functional connectivity

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