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General dysfunction would precede death, and it is loss of vital cuproprotein-based function in still living neurons that we argue is also key to AD

284 When TLR4 binds to its ligand, it activates Myd88, which triggers a series of downstream signaling events, including the activation of the NF-B and MAPK pathways and the production of inflammatory cytokines such as IL-6 and TNF-