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In this study, middle-aged ApoE / mice without training showed lower baroreflex sensitivity in contrast to their younger counterparts, while trained middle-aged mice displayed baroreflex sensitivity similar to or better than that of young mice (Nascimento-Carvalho et al., 2024)

Among others the metabolic shift from O 2 -dependent mitochondrial oxidative phosphorylation (OXPHOS) towards the O 2 -independent glycolytic pathway, known as Pasteur effect, substantially contributes to the maintenance of sufficient ATP production under hypoxic/ischemic conditions 1 , 2