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Beyond endogenous metabolic derangements, inhaled ultrafine particles (e.g., PM. and asbestos fibers) can translocate to the brain via systemic circulation

In general, endocrine milieu of the human fetus with growth retardation is also characterized by low circulating levels of insulin, IGF-I, IGF-II, and IGFBP-3, and high levels of GH and IGFBP-1[185, 192, 193]