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Daily running distances increased by approximately 150% in exercised mice receiving 5-Amino-1MQ treatment, compared to 75% increase in exercise-only groups, with the treatment group maintaining elevated performance more consistently over the 8-week study period

BMJ Open 10

This exceptional selectivity profile enables researchers to attribute observed effects specifically to NNMT inhibition, rather than off-target activities that plague less specific compounds

This dual preservation of both NAD+ and methylation resources represents a unique mechanism among metabolic modulators, positioning 5-amino-1MQ as a bridge between energy metabolism and epigenetic regulation