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It remains unclear whether this loss is independent of associated B cell defects caused by the truncated mutation (98)

While it might seem logical that a higher C rating is always better, this isnt necessarily the case

Impaired DNA repair capacity, exemplified by excision repair cross-complementation group 1 (ERCC1) deficiency, accelerates hematopoietic senescence and compromises immune cell reconstitution (115,116)